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Browsing American University in Cairo Scholarly Communications by Academic Department "American University in Cairo. Dept. of Biology"

Now showing items 1-20 of 79

Analysis of the D1S80 VNTR locus polymorphism in the Nubian population

Ahmed, Soha Rabie (2016-09-21)

D1S80 (1p35-p36), variable Number of tandem repeat (VNTR,) is a minisatellite molecular genetic marker. It is known by its high polymorphism that makes it a powerful marker in the forensic applications, paternity testing, ...
Analysis of the thermal stability of mercuric reductase from the hot brine environment of Atlantis II in the Red Sea by site-directed mutagenesis: Structural interpretation of thermolabile and enhanced thermostable mutants

Galal, Mohamad Maged (2017-05-15)

The lower convective layer (LCL) of the Atlantis II (ATII) deep brine is a unique environment located in the central Red Sea at a depth of 2000-2200 meters. It is characterized by high salinity, temperature of 68οC and ...
Antibiotic resistance in Red Sea brine pools

Elbehery, Ali Hassan Ali (2016-05-23)

Antibiotic resistance (AR) is a complex problem with a global clinical impact. However, did this phenomenon begin in conjunction with the medical use of antibiotics or is it older? Studying AR in pristine environments could ...
ATP synthase: investigating its in vivo rotation and testing the inhibitory effects of diarylquinolines

Radwan, Sarah Hassan (2011-01-18)

The rotation of the central subunits of ATP synthase relative to the surrounding parts has been observed by several techniques, however, most previous studies were carried out using the purified protein immobilized on glass ...
Bacterial production of human discoidin domain receptor 2 (DDR2) kinase and its gatekeeper mutants to assess activation by phosphorylation

Abdel Azeem, Dina Allam (2011-01-15)

Discoidin domain receptor 2 (DDR2) belongs to a subfamily of receptor tyrosine kinases (RTKs) known as discoidin domain receptors (DDRs). DDRs are characterized by an extracellular discoidin homology domain and being ...
Calcified gelatin nanofibers for guided tissue regeneration using water-based benign solvent: An investigation for periodontal applications

Elsayed, Nihal Abdelnabi (2016-11-13)

Periodontal regeneration, especially guided tissue regeneration (GTR), is one of the expanding applications in the field of tissue engineering. GTR barriers serve an exceptional function in healing various periodontal ...
Characterization of aggresome formation in choroid plexus carcinoma.

Nassar, Marwa Mohamed Ali (2017-05-15)

Protein misfolding is inevitable, 30% of newly synthesized polypeptides can end up misfolded, and such proteins are either refolded or eliminated by cellular quality control pathways. These pathways include the ubiquitin ...
Characterization of the bacterial gut fauna of Phlebotomus papatasi: culture dependent vs. culture independent techniques

El-Ayouty, Nada Mohamad (2011-07-12)

Characterizing the gut bacteria of sand flies is essential not only to identify their influence on host biology, but also to investigate any potential impact on the establishment and development of Leishmania infection, ...
Characterization of variant strains of respiratory adenoviruses isolated in Egypt from 2003 to 2010

Demian, Pola Nashdy (2011-07-12)

Human adenovirus (HAdV) has been associated with acute respiratory disease (ARD) in adult and pediatric patients in Egypt. Worldwide, adenovirus of species B, C, and E are predominantly associated with ARD. As part of ...
Cloning, expression and preliminary characterization of a novel nitrilase from the Red Sea, Atlantis II Deep brine pool using a metagenomic approach

Sonbol, Sarah Ali (2013-12-19)

With the abundance of hazardous nitrile compounds in nature and with the extensive use of them in industries of fine chemicals, the attention towards nitrilases has profoundly increased as biocatalysts in different industries ...
Cofactor of BRCA1 as a modulator of hepatocellular carcinoma growth and migration

El Zeneini, Eman Mahmoud (2015-09-10)

Cofactor of BRCA1 (COBRA1) is one of the four subunits that make up the Negative Elongation Factor Complex (NELF) which is involved in the stalling of RNA polymerase II early during transcription elongation. As such, COBRA1 ...
Correlating the expression levels of COBRA1 (co-factor of BRCA1) with hepatocellular carcinoma development in Egyptian patients

Kamel, Sarah (2013-01-10)

COBRA1 is a co-factor of BRCA1 that was identified to be the Î²-subunit of the NELF complex (Negative elongation factor) which stalls RNA polymerase II and prevents elongation of the message. The reported levels of expression ...
CRISPR diversity in brine pools of the Red Sea: a comparative study of clustered regularly interspaced short palindromic repeats from the Red Sea metagenomes

Lotaief, Mohamed Mohamed (2012-09-09)

Exploration of CRISPR/Cas systems in the unique Red sea Brine pools can provide insights into host-viral interactions in highly extremophile environments. 454 Metagenomic datasets from different strata of Atlantis II, ...
A cross-sectional survey study to assess attitudes towards research misconduct among the community of the American University in Cairo

Felaefel, Marwan Tarek (2015-06-07)

Background: Research misconduct is on the rise globally and it is jeopardizing scientific integrity by breaching the basis of responsible scientific conduct. Available data indicates rising levels of fabrication, ...
Deciphering the unique microRNA signature in human esophageal adenocarcinoma: dissecting esophageal adenocarcinoma progressive profile and its distinctions from gastric cancer

Ali, Rama Ahmed Saad Ahmed (2013-07-29)

Background and Methods: Esophageal adenocarcinoma (EAC) is characterized by its dramatic increase in incidence rates in the US and European countries. The specific miRNA signature that would stratify EAC from other upper ...
Development of immuno- nanoparticles for targeting schistosoma parasites

Abdul-Ghany, Eman Rabie (2016-09-21)

Praziquantel (PZQ) is the drug of choice for treatment of schistosomiasis since its discovery in 1972. According to World Health Organization (WHO), schistosomiasis is the second most prevalent parasitic disease worldwide ...
Development of prototype gold nanoparticle-dased immunoassays for the detection of plasmodium falciparum hsp70

Guirgis, Bassem Samy (2010-12-29)

Biomedical nanotechnology is providing revolutionary opportunities for the rapid and simple diagnosis of many infectious diseases. About half of the world's population are at risk of infection with malaria and diagnostic ...
Direct conversion of mouse fibroblasts into osteoblasts and investigating COBRA1 expression responce

Alaasar, Walid Almoafy (2017-09-14)

Fibroblasts are the most common connective tissue cells and are responsible for the synthesis of extracellular matrix (ECM) and collagen. They are mainly of mesenchymal stem cells (MSCs) origin. Fibroblasts are fully ...
E2 evolutionary motif prediction and identification of drug candidates to prevent hepatitis c virus cellular entry

Danial, Shairy Azmy (2011-09-25)

Hepatitis C Virus (HCV) infection causes around three quarters of worldwide chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Interferon and ribavirin combination therapy is not effective with all HCV ...
Enrichment of extremophilic bacteria from Atlantis II Deep brine sediments using various electron donors & acceptors

Abu Alkheir, Nelly (2013-12-23)

The Atlantis II Deep is the most studied and largest brine pool in the Red Sea. It is an active hydrothermal habitat with unique physical conditions. Its unique characteristics (70°C temperature, 26% salinity, pH 5.2) ...

Now showing items 1-20 of 79

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