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dc.contributor.advisor Azzazy, Hassan M.E. Abbas, Yasmine Houssam ElDin 2015-01-28T12:07:27Z 2016-01-28T22:00:10Z 2014 Fall en_US 2015-01-28
dc.description.abstract Lung cancer is the deadliest solid tumor, leading to the deaths of more individuals than the combination of the three next most lethal cancers which are colon, prostate and breast cancer. According to the IARC, in 2012 lung cancer accounted for 13% (1.83 million) of cancer cases and caused 19% (1.56 million) of cancer deaths worldwide. Despite advances in surgery and drug discovery, lung cancer remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor diagnosis and the lack of targeted drug delivery platforms. The aim of this study was to develop a non-invasive, patient convenient platform for the targeted delivery of chemotherapeutic drugs to cancer in deeper lung tissue. The formulation consisted of inhalable maltodextrin (MD)-based microparticles (MPs) encapsulating chitosan (CS) nanoparticles (NPs) loaded with magnetic nanoparticles (MNPs) and a chemotherapeutic drug. Ionotropic gelation was used for CS NPs synthesis. MNPs were synthesized via hydrothermal method and they were superparamagnetic with magnetic saturation (Ms), coercivity (Hc) and remanence (Mr) of 48.4 Am2/Kg, 9.9x10-4 T and 0.5 Am2/Kg emu/g; respectively. CS NPs provided a sustained release of drug, whereas MNPs encapsulated in CS NPs were able to increase the NP drug release in response to an external magnetic field by 1.7 fold. Cell uptake studies conducted using lung cancer cells (A549) indicated that the CS NPs are rapidly uptaken, and show preferential toxicity to tumor cells in comparison to cultured fibroblasts. NPs were modified with anti-epidermal growth factor receptor antibodies and this modification showed to hinder cellular uptake of NPs. Afterwards, the prepared CS NPs and CS-MNPs were co-spray freeze dried (SFD) with MD. The prepared SFD powders had fine particle fraction (FPF ≤ 5.2 μm) of 40-42 % w/w and mass median aerodynamic diameter (MMAD) of 5-6 μm as determined by the next generation impactor (NGI). A mixture of CS NPs and CS-MNPs could be able to provide a continuous sustained release of drug, with intermittent blouses of drug in response to external stimuli; a drug profile desirable in cancer therapy. In conclusion, the targeted delivery to the lung cancer using the developed formulation seems to be a promising approach. en_US
dc.description.sponsorship Study Abroad Grant by the American University in Cairo and Faculty Research Grant by the American University in Cairo en_US
dc.format.extent 118 p. en_US
dc.format.medium theses en_US
dc.language.iso en en_US
dc.rights Author retains all rights with regard to copyright. en
dc.subject Theranostic Nanoparticles en_US
dc.subject Stimuli-Responsive Nanoparticles en_US
dc.subject USPIONs en_US
dc.subject Deep Lung Tissue en_US
dc.subject Cancer en_US
dc.subject Chitosan en_US
dc.subject.lcsh Thesis (M.S.)--American University in Cairo en_US
dc.subject.lcsh Lungs -- Cancer -- Treatment.
dc.subject.lcsh Cancer -- Treatment.
dc.subject.lcsh Nanoparticles.
dc.subject.lcsh BRCA genes.
dc.subject.lcsh Chemotherapy.
dc.subject.lcsh Drugs -- Side effects.
dc.title Development of inhalable microparticles for drug delivery to deep lung tissues en_US
dc.type Text en_US
dc.subject.discipline Nanotechnology en_US
dc.rights.access This item is restricted for 1 year from the date issued en_US
dc.contributor.department American University in Cairo. Dept. of Chemistry en_US
dc.description.irb American University in Cairo Institutional Review Board approval is not necessary for this item, since the research is not concerned with living human beings or bodily tissue samples. en_US
dc.contributor.committeeMember Afifi, Nagia N
dc.contributor.committeeMember Madkour, Tarek M.
dc.contributor.committeeMember Moustafa, Ahmed

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  • Theses and Dissertations [1733]
    This collection includes theses and dissertations authored by American University in Cairo graduate students.

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