Show simple item record

dc.contributor.advisor Ismail, Yehea El-Sehrawy, Yehia 2020-10-26T13:36:28Z Summer 2020 en_US 2020-10-26
dc.description.abstract Unlike traditional medical equipment that tend to be bulky and expensive, biosensors are portable, versatile, and inexpensive for mass production. Biosensors allow for early detection of disease due to their wide reach which increases the patients’ chances of recovery. The literature presents several biosensor techniques based on DNA hybridization, contact imagers, and capacitance transduction. This thesis presents a ring oscillator based biosensor that uses capacitance to frequency transduction for the detection of viral and cancer diseases. The design features a differential measurement to eliminate the effect of parasitic capacitances on the measurement. In order to mitigate the typical errors of process variations associated with differential designs, the design features an automatic calibration system using a feedback loop from the output to synchronize the sensing and reference oscillators. The design is implemented on Virtuoso Analog Design Environment – Cadence using 130 nm CMOS technology. The design was tested for its ability to synchronize and automatically calibrate its reference ring oscillator to the frequency of the sensing ring oscillator. The design was also tested for its ability to detect and measure frequency changes resulting from introduced capacitive changes to the sensing oscillator in the atto and femto farad ranges. Results from the simulations show that the sensor features ±2.3% process variation compensation, minimum input capacitance of 5 aF, 1 attofarad resolution, and 106 kHz/aF sensitivity. The design’s performance proves its ability to be used for a wide array of sensing applications. en_US
dc.format.extent 85 p. en_US
dc.format.medium theses en_US
dc.language.iso en en_US
dc.rights Author retains all rights with regard to copyright. en
dc.subject Capacitance en_US
dc.subject Frequency en_US
dc.subject Sensor en_US
dc.subject Biosensor en_US
dc.subject Ring Oscillator en_US
dc.subject.lcsh Thesis (M.S.)--American University in Cairo en_US
dc.title Frequency based capacitive biosensor en_US
dc.type Text en_US
dc.subject.discipline Electronics Engineering en_US
dc.rights.access This item is restricted for 2 years from the date issued en_US
dc.contributor.department American University in Cairo. Dept. of Electronics Engineering en_US
dc.embargo.lift 2022-10-26T13:36:28Z
dc.description.irb American University in Cairo Institutional Review Board approval is not necessary for this item, since the research is not concerned with living human beings or bodily tissue samples. en_US
dc.contributor.committeeMember Abou Ouf, Ahmed
dc.contributor.committeeMember Abdel Azeem, Sherif
dc.contributor.committeeMember Ragai, Hani

Files in this item


This item appears in the following Collection(s)

  • Theses and Dissertations [1867]
    This collection includes theses and dissertations authored by American University in Cairo graduate students.

Show simple item record